mRNA vaccine effectiveness against COVID-19-related hospitalisations and deaths in older adults: a cohort study based on data linkage of national health registries in Portugal, February to August 2021
Baltazar Nunes, Ana Paula Rodrigues, Irina Kislaya, Camila Cruz, André Peralta‐Santos, João Lima, Pedro Pinto Leite, Duarte João Sequeira, Carlos Matias Dias, Ausenda Machado
Abstract
Through deterministic data linkage of health registries, mRNA vaccine effectiveness (VE) against COVID-19-related hospitalisations and deaths was measured in 1,880,351 older adults. VE against hospitalisations was 94% (95% confidence interval (CI): 88-97) and 82% (95% CI: 72-89) for those 65-79 and ≥ 80 years old, with no evidence of waning 98 days after dose two. VE against mortality was 96% (95% CI: 92-98) and 81% (95% CI: 74-87) in these two age groups.
Topics & Concepts
MedicineConfidence intervalCoronavirus disease 2019 (COVID-19)Record linkageLinkage (software)Cohort studyCohort2019-20 coronavirus outbreakDemographySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PediatricsInternal medicineEnvironmental healthVirologyOutbreakPopulationDiseaseInfectious disease (medical specialty)BiochemistryGeneSociologyChemistrySARS-CoV-2 and COVID-19 ResearchVaccine Coverage and HesitancyCOVID-19 epidemiological studies