The Protective Effects of Live and Pasteurized Akkermansia muciniphila and Its Extracellular Vesicles against HFD/CCl4-Induced Liver Injury
Shahrbanoo Keshavarz Azizi Raftar, Fatemeh Ashrafian, Abbas Yadegar, Arezou Lari, Hamid Reza Moradi, Arefeh Shahriary, Masoumeh Azimirad, Helia Alavifard, Zhaleh Mohsenifar, Mehdi D. Davari, Farzam Vaziri, Arfa Moshiri, Seyed Davar Siadat, Mohammad Reza Zali
Abstract
Akkermansia muciniphila , as a member of the gut microbiota, has been proposed as a next-generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality in patients with chronic liver disease.
Topics & Concepts
Akkermansia muciniphilaCarbon tetrachlorideLiver injuryHepatic stellate cellFibrosisBiologyCCL4LipopolysaccharidePharmacologyGut floraImmunologyPathologyMedicineEndocrinologyChemistryOrganic chemistryLiver Disease Diagnosis and TreatmentLiver physiology and pathologyLiver Disease and Transplantation