Penicimeroterpenoids A–C, Meroterpenoids with Rearrangement Skeletons from the Marine-Derived Fungus <i>Penicillium</i> sp. SCSIO 41512

Abstract

Three novel andrastin-type meroterpenoids, penicimeroterpenoids A–C (1–3), possessing two unprecedented skeletons consisting of fused 6/5/6/6/7 and 6/5/6/6/4 polycyclic systems, were obtained from the marine-derived fungus Penicillium sp. SCSIO 41512. Their structures were determined by spectroscopic methods, and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for 1 and quantum chemical calculations of ECD spectra for 2 and 3, respectively. A plausible biosynthetic pathway for 1–3 was proposed.

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