Au(I)/Au(III)-Catalyzed Sulfonylation of Aryl Iodides for the Synthesis of Various Functionalized Aryl Sulfones
Lizhu Zhang, Wenqian Du, Jiawen Wu, Rongjie Yang, E Xiu‐tian‐feng, Junfeng Wang, Zhonghua Xia
Abstract
A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C–S coupling, a variety of functionalized sodium sulfinates, such as CF 3, CHF 2, CH 3, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.
Topics & Concepts
ArylChemistryCatalysisCombinatorial chemistryOrganic chemistryMedicinal chemistryAlkylSulfur-Based Synthesis TechniquesCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods