A bioinspired polydopamine–FeS nanocomposite with high antimicrobial efficiency <i>via</i> NIR-mediated Fenton reaction
Na Xu, Qian-Qian Huang, Li Shi, Jia Wang, Xiangrong Li, Wei Guo, Dong Yan, Tianjun Ni, Zhijun Yang, Yunhui Yan
Abstract
. The near-infrared (NIR) light-mediated release of ferrous ions could reach about 26.5% under weakly acidic conditions, further triggering the Fenton reaction to produce toxic hydroxyl radicals (·OH) in the presence of hydrogen peroxide. The antibacterial mechanism could be attributed to cell membrane damage and cellular content leakage with the synergistic effect of PTT and CDT. This study highlighted the germicidal efficacy of PDA@FeS NPs and provided a new strategy for designing and developing next-generation antibacterial platforms.
Topics & Concepts
FerrousHydrogen peroxideChemistryPhotothermal therapyNanocompositeCoprecipitationNanoparticleBiocompatibilitySulfideAntibacterial activityChemical engineeringCombinatorial chemistryNanotechnologyMaterials scienceInorganic chemistryOrganic chemistryEngineeringGeneticsBacteriaBiologyNanoplatforms for cancer theranosticsAdvanced Photocatalysis TechniquesAdvanced Nanomaterials in Catalysis