The role of hydrophilic linkers in next-generation antibody-drug conjugates
Qi Fu, Xueqing Kong, Y. J. Liu, Meitong Liu, K. H. G. Huang, Peng George Wang, Kui Wu
Topics & Concepts
LipophilicityChemistryProdrugConjugateCombinatorial chemistryDruggabilityDrug deliveryIn vivoDrug carrierDrugPharmacokineticsNanomedicineBiomoleculeAqueous solutionLinkerSmall moleculeBiophysicsPharmacologyCytotoxicityPEGylationChemical synthesisPharmacophoreChemical modificationPharmacodynamicsTargeted drug deliveryBiodistributionPretargetingBiological activityAmphiphileBioconjugationIn vitroBiocompatible materialSelf-healing hydrogelsPhosgeneLiposomeHER2/EGFR in Cancer ResearchRadiopharmaceutical Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies Research