Apoptosis Regulators Bcl-2 and Caspase-3
Piret Hussar
Abstract
Apoptosis, programmed cell death, has a central role in developmental biology and in maintaining the equilibrium of renewing tissues. A founding member of the Bcl-2 family of regulatory proteins for apoptosis is Bcl-2, which is encoded by the BCL2 gene. Caspase-3 shares typical features with all caspases, including the role of acting as a crucial mediator of apoptosis.
Topics & Concepts
ApoptosisCaspaseCell biologyMediatorInhibitor of apoptosis domainIntrinsic apoptosisProgrammed cell deathCaspase 2BiologyBcl-2 familyGeneticsCell death mechanisms and regulationMitochondrial Function and PathologyInflammasome and immune disorders