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First unequivocal identification of the critical acyl radicals from the anti-tuberculosis drug isoniazid and its hydrazide analogs by complementary applications of ESR spin-trapping and HPLC/MS methods

Qin Li, Chun‐Hua Huang, Li Mao, Bo Shao, Ben‐Zhan Zhu

2020Free Radical Biology and Medicine17 citationsDOI

Topics & Concepts

HydrazideIsoniazidChemistryRadicalIsonicotinic acidAdductSpin trappingCombinatorial chemistryOrganic chemistryTuberculosisMedicinePathologyPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Biological EvaluationStructural and Chemical Analysis of Organic and Inorganic Compounds
First unequivocal identification of the critical acyl radicals from the anti-tuberculosis drug isoniazid and its hydrazide analogs by complementary applications of ESR spin-trapping and HPLC/MS methods | Litcius