Smaller size packs a stronger punch - Recent advances in small antibody fragments targeting tumour-associated carbohydrate antigens
Sana Khan Khilji, Charlotte Op ’t Hoog, David Warschkau, Jost Lühle, Felix Goerdeler, Anika Freitag, Peter H. Seeberger, Oren Moscovitz
Abstract
. To overcome this issue, many small antibody fragments have come forth, showing similar affinity with better efficiency than their full-length counterparts. Here we review small antibody fragments against specific glycans on tumour cells and highlight their advantages over conventional antibodies.
Topics & Concepts
GlycanMonoclonal antibodyAntibodyAntigenImmune systemGlycobiologyGlycosylationCancerBiologyChemistryCancer researchImmunologyCell biologyGlycoproteinMolecular biologyBiochemistryGeneticsGlycosylation and Glycoproteins ResearchMonoclonal and Polyclonal Antibodies ResearchGalectins and Cancer Biology