Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2 <sup>+</sup> macrophages
Dominic Henn, Kellen Chen, Tobias Fehlmann, Artem A. Trotsyuk, Dharshan Sivaraj, Zeshaan N. Maan, Clark A. Bonham, Janos A. Barrera, Chyna J. Mays, Autumn H. Greco, Sylvia E. Moortgat Illouz, John Q. Lin, Sydney R. Steele, Deshka S. Foster, Jagannath Padmanabhan, Arash Momeni, Dung Nguyen, Derrick C. Wan, Ulrich Kneser, Michael Januszyk, Andreas Keller, Michael T. Longaker, Geoffrey C. Gurtner
Abstract
macrophages to mitigate fibrosis and promote wound healing, providing a novel effective strategy to develop advanced cell therapies for complex wounds.
Topics & Concepts
Regeneration (biology)TransplantationAngiogenesisTREM2Cell biologyMacrophagePhagocytosisCancer researchChemistryImmunologyMedicineBiologyInflammationBiochemistryMicrogliaSurgeryIn vitroImmune cells in cancerExtracellular vesicles in diseaseImmune Cell Function and Interaction