Synthetic Studies of 2,2‐Difluorobicyclo[1.1.1]pentanes (BCP‐F<sub>2</sub>): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists
Xiaoshen Ma, W.de.S.F. Pinto, Luu N. Pham, David L. Sloman, Yongxin Han
Abstract
Bicyclo[1.1.1]pentanes (BCP's) have been applied in medicinal chemistry as bioisosteres for phenyl groups. In pursuit of novel BCP analogs, we reported the first synthesis of 2,2‐difluorobicyclo[1.1.1]pentanes (BCP–F 2 ) in 2019. Herein, we detail the extension of our effort in the synthesis of BCP‐F 2 analogs.
Topics & Concepts
ChemistryScope (computer science)Bicyclic moleculeCombinatorial chemistryStereochemistryOrganic chemistryProgramming languageComputer scienceFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Reactions of Organic Compounds