Causes of erythrocytosis and its impact as a risk factor for thrombosis according to etiology: experience in a referral center in Mexico City
Antonio Olivas‐Martínez, Eduardo Corona‐Rodarte, Adrián Nuñez-Zuno, Olga Barrales-Benı́tez, Daniel Montante-Montes de, Jesús Delgado-de la Mora, Diana León-Aguilar, Hilda Elizeth Hernández-Juárez, Elena Tuna‐Aguilar
Abstract
BACKGROUND: Thrombotic events are well documented in primary erythrocytosis, but it is uncertain if secondary etiologies increase the risk of thrombosis. This study aimed to determine the causes of erythrocytosis and to identify its impact as a risk factor for thrombosis. METHODS: Data were obtained from patients with erythrocytosis between 2000 and 2017 at a referral hospital in Mexico City. Erythrocytosis was defined according to the 2016 WHO classification. Time to thrombosis, major bleeding, or death were compared among groups of patients defined by the etiology of erythrocytosis using a Cox regression model, adjusting for cardiovascular risk factors. RESULTS: =0.003). CONCLUSION: The risk of thrombosis in CLD with erythrocytosis was comparable to that in patients with PV. Further larger-scale studies are needed to confirm these findings and evaluate the benefits of preventive management of COPD with erythrocytosis similar to PV.