Plasmacytoid Dendritic Cell-Derived Type I Interferon Is Involved in Helicobacter pylori Infection-Induced Differentiation of Schlafen 4-Expressing Myeloid-Derived Suppressor Cells
Xuyan Xiang, Yaping Wu, Hongwei Li, Cun Li, Yan Lu, Qian Li
Abstract
During chronic infection with Helicobacter pylori , Schlafen 4-expressing myeloid-derived suppressor cells (SLFN4 + MDSCs) create a microenvironment favoring intestinal metaplasia and neoplastic transformation. SLFN4 can be induced by alpha interferon (IFN-α), which is mainly secreted from plasmacytoid dendritic cells (pDCs).
Topics & Concepts
BiologyHelicobacter pyloriSecretionImmunologyInterferonTLR9MyeloidHelicobacterMyeloid-derived Suppressor CellIRF7Cellular differentiationCancer researchInnate immune systemImmune systemSuppressorGene expressionGeneBiochemistryDNA methylationGeneticsImmune cells in cancerImmune Cell Function and InteractionIL-33, ST2, and ILC Pathways