Potassium Persulfate‐Glucose Mediated Synthesis of (3)‐<i>S</i>‐Arylthioindoles from Indole and Thiophenols in Water
Nitin Kumar, Rapelly Venkatesh, Sundaram Singh, Jeyakumar Kandasamy
Abstract
Abstract An efficient and eco‐friendly method has been developed for the preparation of functionalized 3‐( S )‐arylthioindoles in good to excellent yields from indoles and aryl thiols in water. The coupling reaction was prompted by K 2 S 2 O 8 in the presence of glucose at room temperature. Broad substrate scope, functional group tolerance, room temperature reactions and metal‐free conditions are the salient features of the developed methodology.
Topics & Concepts
ChemistryPotassium persulfatePersulfateIndole testArylSubstrate (aquarium)Functional groupCombinatorial chemistryCoupling reactionOrganic chemistryCatalysisOceanographyAlkylPolymerizationGeologyPolymerSulfur-Based Synthesis TechniquesSynthesis of Indole DerivativesSynthesis of heterocyclic compounds