Targeting Mitochondrial Network Disorganization is Protective in <i>C. elegans</i> Models of Huntington’s Disease
Emily Machiela, Paige Rudich, Annika Traa, Ulrich Anglas, Sonja K. Soo, Megan M. Senchuk, Jeremy M. Van Raamsdonk
Abstract
can be detrimental in animal models of HD, but that decreasing mitochondrial fragmentation by targeting other genes can be protective. Overall, this study identifies novel therapeutic targets for HD aimed at improving mitochondrial health.
Topics & Concepts
Huntington's diseaseDiseaseCaenorhabditis elegansMedicineMitochondrionBiologyGeneticsBioinformaticsGeneInternal medicineGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms