Ultrafast Response in Nonenzymatic Electrochemical Glucose Sensing with Ni(II)-MOFs by Dimensional Manipulation
Le Wang, Gui-Zhi Guo, Meidi Wang, Heng‐Yu Ruan, Ya‐Pan Wu, Xue‐Qian Wu, Qichun Zhang, Dong‐Sheng Li
Abstract
Metal–organic frameworks (MOFs) are emerging as promising candidates for electrochemical glucose sensing owing to their ordered channels, tunable chemistry, and atom-precision metal sites. Herein, the efficient nonenzymatic electrochemical glucose sensing is achieved by taking advantage of Ni(II)-based metal–organic frameworks (Ni(II)-MOFs) and acquiring the ever-reported fastest response time. Three Ni(II)-MOFs ({[Ni 6 L 2 (H 2 O) 26 ]4H 2 O} n (CTGU-33), {Ni(bib) 1/2 (H 2 L) 1/2 (H 2 O) 3 } n (CTGU-34), {Ni(phen)(H 2 L) 1/2 (H 2 O) 2 } n (CTGU-35)) have been synthesized for the first time, which use benzene-1,2,3,4,5,6-hexacarboxylic acid (H 6 L) as an organic ligand and introduce 1,4-bis(1-imidazoly)benzene (bib) or 1,10-phenanthroline (phen) as spatially auxiliary ligands. Bib and phen convert the coordination mode of CTGU-33, affording structural dimensions from 2D of CTGU-33 to 3D of CTGU-34 or 1D of CTGU-35. By tuning the dimension of the skeleton, CTGU-34 with 3D interconnected channels exhibits an ultrafast response of less than 0.4 s, which is superior to the existing nonenzymatic electrochemical sensors. Additionally, a low detection limit of 0.12 μM (S/N = 3) and a high sensitivity of 1705 μA mM –1 cm –2 are simultaneously achieved. CTGU-34 further showcases desirable anti-interference and cycling stability, which demonstrates a promising application prospect in the real-time detection of glucose.