Discovery of PT-65 as a highly potent and selective Proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease
Lailiang Qu, Shang Li, Limei Ji, Si Luo, Ming Ding, Fucheng Yin, Cheng Wang, Heng Luo, Dehua Lu, Xingchen Liu, Wan Peng, Lingyi Kong, Xiaobing Wang
Topics & Concepts
HyperphosphorylationChemistryProteolysisIn vivoChimera (genetics)Tau proteinBiochemistryAlzheimer's diseasePhosphorylationDiseaseBiologyEnzymeBiotechnologyPathologyGeneMedicineUbiquitin and proteasome pathwaysProtein Degradation and Inhibitors14-3-3 protein interactions