A novel kinase inhibitor, LZT-106, downregulates Mcl-1 and sensitizes colorectal cancer cells to BH3 mimetic ABT-199 by targeting CDK9 and GSK-3β signaling
Zhou Yu, Jiaying Du, Yue Zhao, Yuan Gao, Yongxu Li, Kai Zhao, Na Lu
Topics & Concepts
Cancer researchDownregulation and upregulationKinaseColorectal cancerApoptosisPhosphorylationBlotCell cultureCancerBiologyCell biologyGeneGeneticsChronic Lymphocytic Leukemia ResearchCancer-related Molecular PathwaysAdvanced Breast Cancer Therapies