Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication
Xueyan Zhang, Haojie Hao, Li Ma, Yecheng Zhang, Xiao Hu, Zhen Chen, Di Liu, Jianhui Yuan, Zhangli Hu, Wuxiang Guan
Abstract
Internal chemical modifications of viral RNA play key roles in the regulation of viral replication and gene expression. Although potential internal modifications have been reported in SARS-CoV-2 RNA, the function of the SARS-CoV-2 N6-methyladenosine (m 6 A) modification in the viral life cycle is unclear.
Topics & Concepts
RNAViral replicationCoronavirusBiologyRNA-dependent RNA polymeraseGene knockdownN6-MethyladenosineRNA silencingVirologyCell biologyMethyltransferaseGeneRNA interferenceGeneticsVirusCoronavirus disease 2019 (COVID-19)MedicineMethylationInfectious disease (medical specialty)PathologyDiseaseRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing