The Prophage and Plasmid Mobilome as a Likely Driver of Mycobacterium abscessus Diversity
Rebekah M. Dedrick, Haley G. Aull, Deborah Jacobs‐Sera, Rebecca A. Garlena, Daniel A. Russell, Bailey E. Smith, Vaishnavi Mahalingam, Lawrence Abad, Christian H. Gauthier, Graham F. Hatfull
Abstract
Mycobacterium abscessus is an important emerging pathogen that is challenging to treat with current antibiotic regimens. There is substantial genomic variation in M. abscessus clinical isolates, but little is known about how this influences pathogenicity and in vivo growth.
Topics & Concepts
ProphagePlasmidDiversity (politics)Mycobacterium abscessusGeneticsBiologyMicrobiologyMycobacteriumBacteriaDNAEscherichia coliGenePolitical scienceBacteriophageLawMycobacterium research and diagnosisBacteriophages and microbial interactionsTuberculosis Research and Epidemiology