A comparative review of immunoassays for COVID-19 detection
Elham Mohit, Zahra Rostami, Hossein Vahidi
Abstract
: Serology testing could be considered as a part of diagnostic panel two-week post symptom onset. Higher sensitivity for serology-based tests could be achieved by determining combined IgG/IgM titers. Furthermore, higher sensitive serological test detecting neutralization antibody could be developed by targeting spike (S) antigen. It was also demonstrated that the sensitivity of ELISA/CLIA-based methods are higher than LFIA devices.
Topics & Concepts
MedicineCoronavirus disease 2019 (COVID-19)Gold standard (test)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)SerologyReverse transcription polymerase chain reactionCoronavirus2019-20 coronavirus outbreakPolymerase chain reactionContact tracingReal-time polymerase chain reactionImmunologyDiseaseInfectious disease (medical specialty)AntibodyGeneOutbreakInternal medicineBiologyMessenger RNAGeneticsSARS-CoV-2 detection and testingSARS-CoV-2 and COVID-19 ResearchBiosensors and Analytical Detection