Investigation of the Mechanism and Chemistry Underlying Staphylococcus aureus <i>'</i> Ability to Inhibit Pseudomonas aeruginosa Growth <i>In Vitro</i>
Lasse Kvich, Stephanie Crone, Mads Holm Christensen, Rita de Cássia Lemos Lima, Morten Alhede, Morten Alhede, Dan Stærk, Thomas Bjarnsholt
Abstract
Chronic infections affect a growing part of the population and are associated with high societal and personal costs. Multiple bacterial species are often present in these infections, and multispecies infections are considered more severe than single-species infections. Staphylococcus aureus and Pseudomonas aeruginosa often coexist in chronic infections. However, the interactions between these two species and their coexistence in chronic infections are not fully understood. By exploring in vitro interactions, we found a novel S. aureus-mediated inhibition of P. aeruginosa, and we suggested a model of the coexistence of the two species in chronic infections. With this study, we enhanced our understanding of the pathogenesis of chronic multispecies infections, which is crucial to paving the way for developing improved treatment strategies.