Mitochondrial transplantation rescues Ca2+ homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy
Shuang Li, Jianchao Zhang, Wanrong Fu, Jinhua Cao, Zhonggen Li, Xiaoxu Tian, Meng Yang, Jing Zhao, Chuchu Wang, Yangyang Liu, Mengduan Liu, Xiaoyan Zhao, Xiaowei Li, Jianzeng Dong, Yuanming Qi
Abstract
homeostasis imbalance in SLC25A3-KO hiPSC-CMs. Finally, we explored the prospective therapeutic implications of mitochondrial transplantation in rescuing SLC25A3-related HCM.
Topics & Concepts
Missense mutationTransplantationBiologyMitochondrial diseaseMitochondrionHomeostasisCardiomyopathyInternal medicineHypertrophic cardiomyopathyMuscle hypertrophyLactic acidosisEndocrinologyHeart failureCell biologyPhenotypeMedicineGeneticsMitochondrial DNAGeneMitochondrial Function and PathologyCardiomyopathy and Myosin StudiesGenetics and Neurodevelopmental Disorders