Allergen-Specific Immunotherapy With Liposome Containing CpG-ODN in Murine Model of Asthma Relies on MyD88 Signaling in Dendritic Cells
Ricardo Wesley Alberca, Lucas Faustino, Eliane Gomes, Fernanda Peixoto Barbosa Nunes, Mirian Krystel De Siqueira, Alexis Labrada, Rafael Ribeiro Almeida, Niels Olsen Saraiva Câmara, Denise Morais da Fonseca, Momtchilo Russo
Abstract
mite extract. The attenuation of allergic inflammation was not associated with increased numbers of Foxp3-positive or IL-10-producing regulatory T cells or with increased levels of IFN-gamma in the lungs. Instead, the anti-allergic effect of the liposomal formulation was dependent of the innate immune signal transduction generated in CD11c-positive putative dendritic cells expressing MyD88 molecule. Therefore, we highlight the pivotal role of dendritic cells in mediating the attenuation of established allergic lung inflammation following immunotherapy with a liposomal formulation containing allergen plus CpG-ODN.