Nano-enzyme functionalized hydrogels promote diabetic wound healing through immune microenvironment modulation
Chaoyu Pu, Yong Wang, Yuling Li, Yi Wang, Linfeng Li, Honglin Xiang, Qiyuan Sun, Yuan Yong, Hanfeng Yang, Ke Jiang
Abstract
experiments, diabetic rat wounds treated with GelMA@Mg-POM displayed enhanced granulation tissue genesis and collagen production, as evidenced by HE and Masson staining. Immunohistochemistry demonstrated the ability of GelMA@Mg-POM to mitigate macrophage-associated inflammatory responses and promote angiogenesis. Overall, these findings suggest that GelMA@Mg-POM holds significant promise as a biomaterial for treating diabetic wounds.
Topics & Concepts
Wound healingImmune systemOxidative stressPathophysiologySelf-healing hydrogelsAmputationDiabetic footChemistryInflammationDiabetes mellitusCell biologyMedicineImmunologyCancer researchBiochemistryInternal medicineSurgeryBiologyEndocrinologyPolymer chemistryWound Healing and TreatmentsPressure Ulcer Prevention and ManagementBurn Injury Management and Outcomes