Ischemic damage to every segment of the oxidative phosphorylation cascade elevates ETC driving force and ROS production in cardiac mitochondria
Sarah Kuzmiak‐Glancy, Brian Glancy, Matthew W. Kay
Abstract
This integrative analysis is the first to assess how myocardial ischemia alters the mitochondrial driving forces and the degree to which individual segments of the mitochondrial energy transduction pathway contribute to diminished function following ischemia. This investigation demonstrates that increased reactive oxygen species production following ischemia is related to a lower effective activity of the electron transport chain and a greater driving force down the electron transport chain.
Topics & Concepts
Oxidative phosphorylationMitochondrionCascadePhosphorylationCell biologyOxidative stressReactive oxygen speciesOxidative damageChemistryCardiologyBiophysicsInternal medicineMedicineBiologyBiochemistryChromatographyMitochondrial Function and PathologyCardiac Ischemia and ReperfusionAdvanced MRI Techniques and Applications