Lipolysis-derived linoleic acid drives beige fat progenitor cell proliferation
Ichitaro Abe, Yasuo Oguri, Anthony R.P. Verkerke, Lauar de Brito Monteiro, Carly M. Knuth, Christopher Auger, Yunping Qiu, Gregory P. Westcott, Saverio Cinti, Kosaku Shinoda, Marc G. Jeschke, Shingo Kajimura
Abstract
. Oral supplementation of linoleic acid was sufficient to stimulate beige progenitor cell proliferation, even under thermoneutral conditions, in a CD36-dependent manner. Together, this study provides mechanistic insights into how diverse pathophysiological stimuli, such as cold and burn injury, promote de novo beige fat biogenesis.
Topics & Concepts
BiologyProgenitor cellCell biologyLinoleic acidCD36Adipose tissueLipolysisArachidonic acidEndocrinologyInternal medicineFatty acidBiochemistryStem cellReceptorEnzymeMedicineAdipose Tissue and MetabolismFatty Acid Research and HealthAdipokines, Inflammation, and Metabolic Diseases