Base-Promoted C–C Bond Activation Enables Radical Allylation with Homoallylic Alcohols
Maximilian Lübbesmeyer, Emily G. Mackay, Mark A. R. Raycroft, Jonas Elfert, Derek A. Pratt, Armido Studer
Abstract
cleavage leads to the formation of the corresponding allylated products along with ketyl radicals that act as single electron reductants to sustain the chain reactions. Substrate scope is documented and the role of base in the C-C bond activation is studied by computation.
Topics & Concepts
ChemistryKetylHomolysisRadicalReagentReactivity (psychology)Bond cleavagePhotochemistryAlkylDouble bondSubstrate (aquarium)Medicinal chemistryOrganic chemistryCatalysisGeologyPathologyMedicineAlternative medicineOceanographyRadical Photochemical ReactionsFluorine in Organic ChemistryCatalytic C–H Functionalization Methods