I<sub>2</sub>-Promoted In Situ Cyclization–Rethiolation Reaction: Synthesis of 2-Aliphatic- or Aromatic-Substituted Indolizines
Peng Zhao, Zhi‐Cheng Yu, Ling-Feng Wang, You Zhou, Yan‐Dong Wu, Yongmin Ma, An‐Xin Wu
Abstract
-promoted one-pot one-step three-component reaction for the synthesis of sulfhydryl indolizines from methyl ketones, 2-pyridylacetate derivatives, and sulfonyl hydrazides via an in situ cyclization-rethiolation strategy has been developed. This protocol shows excellent substrate compatibility, including for chain and cyclic aliphatic methyl ketones, natural product pregnenolone acetate, and phosphorus-containing methyl ketones, affording a series of valuable aliphatic-substituted indolizines in good yields.
Topics & Concepts
ChemistryOrganic chemistrySynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsSynthesis and Characterization of Pyrroles