Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics
Shiqi Ye, Xi Tian, Aihetaimujiang Anwaier, Shiyin Wei, Wangrui Liu, Jiaqi Su, Shuxuan Zhu, Bo Dai, Jun Gu, Yuanyuan Qu, Wenhao Xu, Hailiang Zhang, Dingwei Ye
Abstract
We constructed a PRMTScore system, which showed the potent ability to assess the prognosis, TME characteristics, and immunotherapy response for patients with ccRCC. Moreover, this is the first study to propose that PRMT5 acts as a cancer suppressor in ccRCC.
Topics & Concepts
Clear cell renal cell carcinomaMethylationMethyltransferaseProtein arginine methyltransferase 5Cancer researchBiologyImmunohistochemistryImmunotherapyDNA methylationRenal cell carcinomaImmune systemOncologyMedicineImmunologyGene expressionGeneBiochemistryCancer-related gene regulationEpigenetics and DNA MethylationBladder and Urothelial Cancer Treatments