Synthesis and delivery of a stable phosphorylated ubiquitin probe to study ubiquitin conjugation in mitophagy
Guy Mann, Gandhesiri Satish, Prasad Sulkshane, Shaswati Mandal, Michael H. Glickman, Ashraf Brik
Abstract
Synthesis, delivery and cellular conjugation analysis of differentially phosphorylated ubiquitin probes by parkin E3 ligase during mitophagy.
Topics & Concepts
MitophagyParkinUbiquitinPhosphorylationCell biologyChemistrySubstrate (aquarium)AutophagyNanotechnologyBiochemistryBiologyMaterials scienceMedicinePathologyDiseaseParkinson's diseaseEcologyApoptosisGeneAutophagy in Disease and TherapyUbiquitin and proteasome pathwaysCellular transport and secretion