Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
Mitchell L. Leibowitz, Stamatis Papathanasiou, Phillip A. Doerfler, Logan J. Blaine, Lili Sun, Yu Yao, Cheng‐Zhong Zhang, Mitchell J. Weiss, David Pellman
Topics & Concepts
ChromothripsisBiologyGenome editingCRISPRCas9GeneticsLocus (genetics)GenomeChromosomeChromosomal rearrangementDNAComputational biologyGeneGenome instabilityKaryotypeDNA damageCRISPR and Genetic EngineeringVirus-based gene therapy researchRetinal Development and Disorders