Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice
Yang Guo, Lei Han, Shuang Han, Honghai Tang, Shengyi Wang, Chong Cui, Bing Chen, Huawei Li, Yilai Shu
Abstract
transcript in mice has been proved effective and safe for preventing hearing loss induced by aminoglycosides and, thus, represents a promising genetic approach for the future clinical applications for treating non-inherited hearing loss.
Topics & Concepts
Gene knockdownCRISPRHearing lossGuide RNAHair cellRNA interferenceBiologyGene silencingCas9In vivoSmall hairpin RNALoss functionCochleaRNACell biologyMedicineGeneticsAudiologyCell cultureNeuroscienceGenePhenotypeCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsRNA regulation and disease