Design, synthesis, and in silico insights into dual-inhibition of CDK-6/Aurora A kinase by 2-phenylbenzimidazole-based small molecules
Alaa M. Ali, Samar S. Tawfik, Bhoomendra A. Bhongade, Mohammed A. M. Massoud, Amany S. Mostafa
Topics & Concepts
ChemistryLipinski's rule of fiveStaurosporineIn silicoCyclin-dependent kinaseIC50Docking (animal)KinaseEnzymeCell cycleIn vitroBiochemistryStereochemistryApoptosisProtein kinase AMedicineNursingGeneMicrotubule and mitosis dynamicsCancer-related Molecular PathwaysAdvanced Breast Cancer Therapies