Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice
Mito Kanatsu‐Shinohara, Jiyoung Lee, Takehiro Miyazaki, Hiroko Morimoto, Takashi Shinohara
Abstract
mutant mouse ovaries, which lack Kitl expression but contain only primordial follicles. Healthy offspring without AAV integration are born by natural mating. Therefore, AAV-mediated gene delivery not only provides a means for studying oocyte-granulosa interactions through the manipulation of the oocyte microenvironment but could also be a powerful method to treat female infertility resulting from somatic cell defects.
Topics & Concepts
OocyteBiologyOogenesisInfertilityCell biologyFolliculogenesisSomatic cellFollicular phaseOvarian follicleGene deliveryOffspringAndrologyGeneGeneticsPregnancyEmbryoGenetic enhancementMedicineEmbryogenesisVirus-based gene therapy researchReproductive Biology and FertilityAnimal Virus Infections Studies