<i>N</i>-Glycan and Glycopeptide Serum Biomarkers in Philippine Lung Cancer Patients Identified Using Liquid Chromatography–Tandem Mass Spectrometry
Michael Russelle Alvarez, Qingwen Zhou, Jennyfer Tena, Carlito B. Lebrilla, Gladys C. Completo, Francisco M. Heralde, M. Cabanatan, Ma. Teresa Barzaga, N. Tan-Liu, Guia Imelda Ladrera, Jose Luis J. Danguilan, Jomar F. Rabajante, Isagani Padolina, Ruel C. Nacario
Abstract
-glycans and site-specific glycans are differentially expressed between cases and controls. This report represents the first serum glycan and glycopeptide biomarkers of Philippine lung cancer patients, further demonstrating the utility of mass spectrometry-based glycomic and glycoproteomic methods.
Topics & Concepts
GlycanGlycopeptideLung cancerBiomarkerGlycosylationBiomarker discoveryCancerChemistryGlycoproteinMedicineOncologyProteomicsBiochemistryInternal medicineGeneAntibioticsGlycosylation and Glycoproteins ResearchLung Cancer Research StudiesCarbohydrate Chemistry and Synthesis