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Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects

Abdelsattar M. Omar, Jürgen Bajorath, Saleh Ihmaid, Hany M. Mohamed, Ahmed M. El‐Agrody, Ahmed Mora, Moustafa E. El‐Araby, Hany E. A. Ahmed

2020Bioorganic Chemistry45 citationsDOI

Topics & Concepts

ChemistryMatrix metalloproteinase inhibitorCell cycle checkpointMatrix metalloproteinaseCell cycleApoptosisDNA fragmentationAngiogenesisThiazoleCell growthCancer cellCancer researchPharmacologyBiochemistryCancerProgrammed cell deathStereochemistryBiologyGeneticsProtease and Inhibitor MechanismsPeptidase Inhibition and AnalysisClick Chemistry and Applications
Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects | Litcius