Mitochondrial calcium uniporter complex activation protects against calcium alternans in atrial myocytes
Yuriana Oropeza‐Almazán, Lothar A. Blatter
Abstract
This study provides conclusive evidence that mitochondrial Ca uptake and retention protects from Ca alternans, whereas uptake inhibition enhances Ca alternans. The data suggest pharmacological mitochondrial Ca cycling modulation as a potential therapeutic strategy for alternans-related cardiac arrhythmia prevention.
Topics & Concepts
UniporterCalciumMyocyteChemistryMitochondrionAtrial myocytesBiophysicsInternal medicinePharmacologyBiologyMedicineBiochemistryCytosolEnzymeMitochondrial Function and PathologyCardiac electrophysiology and arrhythmiasIon channel regulation and function