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Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein

Yukari Ono, Masayuki Ninomiya, Daiki Kaneko, Amol D. Sonawane, Taro Udagawa, Kaori Tanaka, Atsuyoshi Nishina, Mamoru Koketsu

2020Bioorganic Chemistry27 citationsDOI

Topics & Concepts

QuinoxalineChemistryOxadiazoleCytotoxicityApoptosisMorpholinePiperidineCell culturePiperazineCell growthBiochemistryStereochemistryIn vitroBiologyMedicinal chemistryOrganic chemistryGeneticsSynthesis and Biological EvaluationCAR-T cell therapy researchCancer therapeutics and mechanisms
Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein | Litcius