Polyphenols from traditional Chinese medicine and Mediterranean diet are effective against Aβ toxicity <i>in vitro</i> and <i>in vivo</i> in <i>Caenorhabditis elegans</i>
Adriana Gea‐González, Samanta Hernández‐García, Paula Henarejos‐Escudero, Pedro Martínez‐Rodríguez, Francisco García‐Carmona, Fernando Gandía‐Herrero
Abstract
aggregation assays in which 1 mM hydroxytyrosol reduced the amyloid plaques in the mutant strain CL2331 by 43%. The neuroprotective effect was evaluated in chemotaxis experiments carried out with transgenic strain CL2355 that expresses the human amyloid-β peptide in the neurons. The chemotaxis index was improved by 240% when the neuron-impaired animals were treated with 1 mM hydroxytyrosol. The results indicate that the four molecules would be viable candidates to develop nutraceuticals that interfere in amyloid-β peptide aggregation and, consequently, prevent and/or treat Alzheimer's disease.
Topics & Concepts
HydroxytyrosolBaicaleinIn vivoPharmacologyResveratrolChemistryFlavonesNutraceuticalPolyphenolCaenorhabditis elegansBiochemistryAmyloid betaBiologyPeptideAntioxidantChromatographyBiotechnologyGeneFlavonoids in Medical ResearchAlzheimer's disease research and treatmentsNatural Antidiabetic Agents Studies