Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
Khaled El‐Adl, Helmy Sakr, Reda G. Yousef, Ahmed B. M. Mehany, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A. ElSohly, Hamada S. Abulkhair, Ibrahim H. Eissa
Topics & Concepts
SorafenibChemistryDoxorubicinCell cultureIC50PharmacologyDocking (animal)QuinoxalinePaclitaxelCell growthCancer researchIn vitroCancerBiochemistryChemotherapyInternal medicineBiologyMedicineGeneticsOrganic chemistryNursingHepatocellular carcinomaSynthesis and Biological EvaluationBioactive Compounds and Antitumor AgentsSynthesis and biological activity