Engineering the Interface between Inorganic Nanoparticles and Biological Systems through Ligand Design
Rui Huang, David C. Luther, Xianzhi Zhang, Aarohi Gupta, Samantha A. Tufts, Vincent M. Rotello
Abstract
Nanoparticles (NPs) provide multipurpose platforms for a wide range of biological applications. These applications are enabled through molecular design of surface coverages, modulating NP interactions with biosystems. In this review, we highlight approaches to functionalize nanoparticles with "small" organic ligands (Mw < 1000), providing insight into how organic synthesis can be used to engineer NPs for nanobiology and nanomedicine.
Topics & Concepts
NanomedicineNanotechnologyNanoparticleMaterials scienceLigand (biochemistry)ChemistryBiochemistryReceptorAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery