A High-Salt Diet Exacerbates Liver Fibrosis through <i>Enterococcus</i> -Dependent Macrophage Activation
Xujun Zhang, Yan Liang, Jingjing Jiang, Chong Lu, Fan Shi, Qingyi Cao, Yanhui Zhang, Hongyan Diao
Abstract
induce liver fibrosis in mice. These results indicate that an HSD can exacerbate liver fibrosis by altering the gut microbiota composition, thus impairing intestinal barrier function. Therefore, this may serve as a new target for liver fibrosis therapy and gut microbiota management.
Topics & Concepts
FibrosisLiver fibrosisMacrophageGut floraEnterococcusBiologyHepatic fibrosisInternal medicineImmunologyMedicineMicrobiologyBiochemistryAntibioticsIn vitroLiver Disease Diagnosis and TreatmentDiet and metabolism studiesDiet, Metabolism, and Disease