A Soluplus/Poloxamer 407-based self-nanoemulsifying drug delivery system for the weakly basic drug carvedilol to improve its bioavailability
Han Han, Yun Li, Zhenwei Peng, Kaiqi Long, Chunli Zheng, Weiping Wang, Thomas J. Webster, Liang Ge
Topics & Concepts
BioavailabilityCarvedilolDrug deliveryPharmacologyChemistryDrugSolubilityPharmacokineticsPoloxamer 407PoloxamerChromatographyMedicineInternal medicineOrganic chemistryCopolymerHeart failurePolymerDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsAnalytical Methods in Pharmaceuticals