Exploiting Broad-Spectrum Chimeric Lysin to Cooperate with Mupirocin against Staphylococcus aureus-Induced Skin Infections and Delay the Development of Mupirocin Resistance
Xiaochao Duan, Xinxin Li, Xiangmin Li, Shuang Wang, Fen-Qiang Zhang, Ping Qian
Abstract
Staphylococcus aureus , as an Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter species (ESKAPE) pathogen, can escape the elimination of existing antibiotics. At present, phages and phage lysins against S. aureus infections are considered alternative antibacterial agents.
Topics & Concepts
MupirocinStaphylococcus aureusLysinMicrobiologyBroad spectrumMedicineStaphylococcal infectionsAntibiotic resistanceMethicillin-resistant Staphylococcus aureusAntibioticsBiologyBacteriaGeneticsChemistryGeneBacteriophageEscherichia coliCombinatorial chemistryAntimicrobial Peptides and ActivitiesAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensing