A Photo‐Responsive Hollow Manganese/Carbon Hybrid Nanosphere for Wound Disinfection and Healing
Mingzhu Lu, Shanshan Li, Xiaolu Xiong, Zhijun Huang, Bolong Xu, Yunhang Liu, Qingyuan Wu, Nier Wu, Huiyu Liu, Dongsheng Zhou
Abstract
Abstract The emergence of multi‐drug resistant (MDR) bacteria poses a serious threat to human health. It has become imperative to develop efficient antimicrobial strategies. Here, a manganese‐doped dopamine‐derived hollow carbon sphere (MnO x /HNCS) is developed as a nanozyme and photothermal agent for the synergistic treatment of MDR bacterial infections. MnO x /HNCS possesses oxidase, superoxide dismutase, and peroxidase like activities and implements self‐cascading enzymatic catalysis to produce superoxide anion (O 2 •− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (•OH). Importantly, near‐infrared light facilitates the electron transport of MnO x /HNCS, allowing it to exhibit stable photothermal effects and photo‐enhanced enzymatic activity. Thereby MnO x /HNCS displays a broad‐spectrum synergistic antibacterial efficiency in vitro against six MDR pathogens based on the above photo‐regulated properties. In vivo experiments further demonstrate the excellent antibacterial efficiency of MnO x /HNCS in the MDR bacteria‐infected wound model. Notably, MnO x /HNCS not only has excellent disinfection capacity, but also can accelerate wound healing by stimulating the deposition of the extracellular matrix and reepithelialization. This study proposes a promising antibiotics‐alternative broad‐spectrum antibacterial strategy and paves a new avenue for the establishment of multifunctional photo‐responsive synergistic therapeutic platform.