m6A RNA modification pathway: orchestrating fibrotic mechanisms across multiple organs
Xiangfei Huang, Zilu Yu, Juan Tian, Tao Chen, Anhua Wei, Chao Mei, S. R. Wayne Chen, Yong Li
Abstract
Organ fibrosis, a common consequence of chronic tissue injury, presents a significant health challenge. Recent research has revealed the regulatory role of N6-methyladenosine (m6A) RNA modification in fibrosis of various organs, including the lung, liver, kidney, and heart. In this comprehensive review, we summarize the latest findings on the mechanisms and functions of m6A modification in organ fibrosis. By highlighting the potential of m6A modification as a therapeutic target, our goal is to encourage further research in this emerging field and support advancements in the clinical treatment of organ fibrosis.
Topics & Concepts
BiologyRNAComputational biologyCell biologyBioinformaticsGeneticsGeneRNA modifications and cancerCardiac Structural Anomalies and RepairHVDC Systems and Fault Protection