Effect of Norovirus Inoculum Dose on Virus Kinetics, Shedding, and Symptoms
Yang Ge, W. Zane Billings, Antone R. Opekun, Mary K. Estes, David Y. Graham, Juan S. León, Katia Koelle, Ye Shen, Robert L. Atmar, Benjamin A. Lopman, Andreas Handel
Abstract
genomic equivalent copies. Onset time of viral shedding in feces decreased from 1.4 to 0.8 days, and time of peak viral shedding decreased from 2.3 to 1.5 days. Time to symptom onset decreased from 1.5 to 0.8 days. One type of symptom score increased. An increase in norovirus dose was associated with more rapid shedding and symptom onset and possibly increased severity. However, the effect on virus load and shedding was inconclusive.
Topics & Concepts
NorovirusViral sheddingMurine norovirusFecesVirusVirologyBiologyViral loadMicrobiologyViral gastroenteritis research and epidemiologyRespiratory viral infections research