Nanoscale Covalent Organic Frameworks with Donor–Acceptor Structure for Enhanced Photothermal Ablation of Tumors
Rui Xia, Xiaohua Zheng, Chaonan Li, Xiaodie Yuan, Jian Wang, Zhigang Xie, Xiabin Jing
Abstract
Covalent organic frameworks (COFs) have shown great potential in catalysis and the biomedical fields, but monodisperse COFs with tunable sizes are hard to obtain. Herein, we successfully developed a series of COFs based on electron donor-acceptor strategy in mild conditions. The synthetic COFs exhibit excellent colloidal stability with uniform spherical morphology. The sizes can be flexibly adjusted by the amount of catalyst, and the absorption spectra also vary with the sizes. By changing the electron-donating ability of the monomers, the corresponding COFs possess a wide range of absorption spectra, which can be even extended to the second near-infrared biowindow. The obtained COFs possess potent photothermal activity under laser irradiation, and could inhibit the growth of tumors effectively. This work provides a strategy for the synthesis of monodisperse COFs with variable absorption for their potential applications.