Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases
Madhulika Tripathi, Paul M. Yen, Brijesh Kumar Singh
Abstract
The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.
Topics & Concepts
Estrogen-related receptor alphaNuclear receptorBiologyEstrogen receptor alphaEstrogen receptorTranscription factorEstrogenEstrogen-related receptor gammaAutophagyReceptorEstrogen receptor betaCell biologyGeneEndocrinologyBiochemistryCancerGeneticsBreast cancerApoptosisEstrogen and related hormone effectsGenomics, phytochemicals, and oxidative stressNuclear Receptors and Signaling